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  • 10 Days in Italy: The Ultimate City-to-City Train Itinerary

    Klook Team
    Klook Team
    Last updated 27 Feb 2026
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    10-day Italy Itinerary banner
    Looking for Italy itinerary ideas for your Italy vacation? Begin on an unforgettable Italian journey with the 2 train providers in Italy, Trenitalia and Italo!
    If you're a culture enthusiast, a history buff, or someone looking the beauty of Italy's diverse landscapes, the classic Italy guide below offers a carefully planned route that captures the essence of this enchanting country, making your trip to Italy easier!
    From the iconic landmarks of Rome and the artistic treasures of Florence to the sun-kissed Amalfi Coast and the romantic allure of Venice, this itinerary ensures that every day is a new turn in your Italian trip. Enjoy yourself in the rich history, savor the culinary delights, and discover hidden gems with our insightful day trips.

    Exploring the main stations of Italy

    Before planning your Italy itinerary ideas, it's best to familiarize yourself with the main train stations in different cities. You'll come across a network of stations, including a central train station in the center of the city and often one or two additional stations in the suburbs.
    Aside from learning the main train station, you should choose the appropriate departing and arrival stations as it’s important in avoiding inconvenience and unexpected detours! Central stations like Milan's Milano Centrale or Rome's Roma Termini, offer convenient access to the city's core attractions. For your easy reference in your Italy itinerary, here are some stations to remember:

    Central Stations

    Suburb Stations

    Milano Centrale

    Milano Porta Garibaldi

    Roma Termini

    Roma Tiburtina

    Roma Ostiense

    Florence Santa Maria Novella (also Firenze S.M. Novella / Firenze S.M.N)

    Firenze Campo di Marte

    Venezia S. Lucia

    Venezia Mestre

    Napoli Centrale

    Napoli Afragola

    Bologna Centrale

    Bologna Mazzini

    Palermo Centrale

    Messina Centrale

    Catania Centrale

    Understanding Italo vs. Trenitalia

    Understanding the differences between Italy’s two major train carriers, Italo and Trenitalia, is a must when planning your Italian getaway! These two major carriers give different experiences in terms of pricing, service quality, and coverage.
    A red Italo train
    Italo, a more luxurious choice
    Seats inside a train
    Interior of Italo trains
    Known for its sleek, modern trains, Italo is usually a better choice if you’re looking a more luxurious journey with amenities like free Wi-Fi, power outlets, and onboard entertainment. But, if you’re particular about budget, it’s best to keep in mind that ticket prices can be a bit higher.
    A red train
    Trenitalia is the primary train operator in Italy
    If you’re looking for a more affordable option, Trenitalia has a wider coverage network and ticket options, so it’s the budget-friendly choice. When choosing between the two, consider your priorities if it's luxury and comfort or cost-efficiency.
    In terms of ticket classes, both gives you different options, each with its own perks. Some perks refund and exchange policies, seat and carriage amenities, and overall luxury. 
    First-class tickets gives you access to more comfortable seating, complimentary refreshments, and greater flexibility in changing travel plans. But, don’t get it wrong,; second-class tickets are more budget-friendly and also provide a comfortable journey! 

    Ticket types

    Most Italian railways like Italo and Trenitalia offer four types of train tickets: first class (refundable), first class (with different conditions), second class (refundable), and second class (with different conditions). If you will be taking many separated train rides, consider getting point-to-point tickets; this gives you more flexibility!

    10-day itinerary in Italy: Ride the Rails with Italo and Trenitalia 

    10-day itinerary in Italy map
    Suggested 10-day itinerary in Italy

    Itinerary

    Route

    Train carrier

    Train duration

    Price in EUR

    Link to book

    Milan > Rome

    Italo, Trenitalia

    3 hours 30 mins

    From EUR 42 / adult

    Milan to Rome train

    Rome > Florence

    Italo, Trenitalia

    1 hour 30 mins

    From EUR 22 / adult

    Rome to Florence train

    Florence > Venice

    Italo, Trenitalia

    2 hours 15 mins

    From EUR 24 / adult

    Florence to Venice train

    Venice > Milan

    Italo, Trenitalia

    2 hours 30 mins

    From EUR 22 / adult

    Venice to Milan train

    Rome <> Naples / Amalfi Coast / Capri

    Italo, Trenitalia

    1 hour 30 mins

    From EUR 23 / adult

    Rome to Naples train

    Naples <> Pompeii

    Trenitalia

    30 mins

    From EUR 3 / adult

    Naples to Pompeii train

    Day 1-2: Milan

    Duomo di Milano in sunset
    Duomo di Milano in sunset
    You can start your 10 days in Italy in stylish Milan, where Gothic architecture meets modern elegance. You can roam around and go beneath the beautiful towers of the Duomo di Milano, then walk through the grand Galleria Vittorio Emanuele II for luxury boutiques and historic cafés.
    Klook Tip: If you love art, you should book ahead to see The Last Supper at Santa Maria delle Grazie.
    After taking in Milan’s iconic landmarks, slow the pace and experience its local side. Relax in green spaces like Parco Sempione or spend your evenings along the lively Navigli canals. Sip an aperitivo, enjoy Lombard cuisine, and take in the city’s cosmopolitan vibe. Milan sets a bold and beautiful tone for your Italian rail adventure.

    Day 3-5: Rome

    The Colosseum in Rome
    Explore the timeless beauty starting with the Colosseum in the heart of Rome
    Next, hop on a high-speed train to Rome, where you can visit ancient ruins and lively street life. We recommend starting with the iconic attractions like the Colosseum, Roman Forum, and Palatine Hill on a guided experience like the Colosseum, Roman Forum and Palatine Hill Tour. After that, explore the Pantheon and toss a coin into the Trevi Fountain to ensure your return.
    As the sun sets, walk through Trastevere’s charming lanes or unwind at the Spanish Steps. Be sure to set aside time for Vatican City, home to St. Peter's Basilica and the Sistine Chapel.  For a more fun experience, join the Vatican Museums, Sistine Chapel & St. Peter's Basilica Tour!
    Rome fills your 10 days in Italy with powerful history, unforgettable art, and incredible food.
    St. Peter's Basilica in Vatican City
    Photo Credit: Anastasiya Lobanovskaya on Pexels
    St. Peter's Square in Vatican City
    St. Peter's Square in Vatican City
    Among the ancient splendors, Vatican City, an independent city-state within Rome, holds treasures such as St. Peter's Basilica and the Sistine Chapel, adorned with Michelangelo's masterpieces. The Vatican Museums house an extensive collection of art and artifacts, providing a journey through centuries of artistic expression. It is worth it to take a day trip to visit Vatican City from Rome.
    Klook Tip: To make the most of your time there, book the Vatican Museums, Sistine Chapel & St. Peter's Basilica experience in advance so you can skip the long lines and explore world-famous masterpieces with an expert guide who brings the art and history to life.

    Day 6-7: Florence

    people walking through the busy streets in florence italy
    Photo Credit: Heidi Kaden on Unsplash
    Next, travel to Florence, Tuscany’s artistic heart. Start your day by visiting the red dome of Florence Cathedral, then explore Renaissance masterpieces at the Uffizi Gallery and Accademia. With every step, you’ll feel the city’s creative spirit come alive.
    After exploring Florence’s iconic landmarks, slow down and savor the atmosphere. Walk across the romantic Ponte Vecchio before indulging in Tuscan flavors at Mercato Centrale. If you’re craving scenic views, book the Highlights of Tuscany Day Tour or take a quick trip to Pisa. Florence seamlessly blends art, culture, and rich cuisine into your 10-day Italy itinerary.

    Day 8-10: Venice

    Canals of Venice
    Photo Credit: nextvoyage on Pexels
    Finally, wrap up your 10 days in Italy in magical Venice. Start at Piazza San Marco, admire the beauty of St. Mark’s Basilica, and cross the famous Ponte di Rialto Bridge. Then, glide through the canals on a gondola to truly soak in the city’s timeless charm.
    After exploring the major attractions, explore inside the grand Doge's Palace to uncover Venice’s fascinating past, from lavish council chambers to the eerie Bridge of Sighs. To make your visit seamless, book the Doge’s Palace & St. Mark’s Museums experience  for easy entry and access to rich cultural treasures.
    If you want to see more, you can go beyond the main island and join the Murano and Burano Island Tour. This tour will take you to go around and see colorful houses, watch glassmaking workshops, and enjoy a quieter side of the lagoon. Venice’s dreamy canals and artistic spirit create the perfect finale to your Italian journey!

    (Optional) Naples, Amalfi Coast, or Capri

    A beach with blue waters
    Photo Credit: Daniele Putti on Pexels
    If you have more than 10 days in Italy, consider extending your trip to southern Italy for even more unforgettable experiences. Head south to explore destinations like Naples, the breathtaking Amalfi Coast, or the glamorous island of Capri.
    Naples is alive with energy, history, and incredible food; it’s the birthplace of pizza and the gateway to ancient ruins like Pompeii. Along the Amalfi Coast, you’ll see dramatic cliffs, pastel villages, and turquoise waters create postcard-perfect scenery. Capri offers chic island vibes, sea caves, and stunning coastal views. 
    Adding any of these destinations will give your Italy itinerary even more flavor, beauty, and adventure.

    Why should you consider taking trains to visit Italy?

    Visiting Italy by train has its own perks that will make your trip all the more enjoyable, which are: 
    • Shorter travel time: Train stations are usually in the city center, giving you quick access to major attractions and cutting airport transfer time. While rental cars work well for road trips, trains are often faster for city-to-city travel.
    • Cost-effective: Book early to secure lower fares, especially during peak seasons. Summer tickets can cost up to 3x more than off-season prices. (KlookTip: Travel in winter for better deals if you’re budget-conscious.)
    • Hassle-free travel: Enjoy e-tickets, skip airport-style check-ins, and reduce travel stress. Flexible ticket options make boarding simple and smooth.
    Ample luggage space: Trains offer generous storage for large or heavy bags, without the extra baggage fees common on budget airlines.

    FAQs about 10 days in Italy

    Is 10 days enough to see Italy?

    Yes, 10 days in Italy is enough to see major highlights. You won’t see everything, but you can experience Rome, Florence, and Venice, and even add day trips. The key is to plan wisely and book tickets in advance. Focus on quality experiences instead of rushing.

    What is the best route for a 10-day Italy itinerary?

    A popular route is Rome → Florence → Venice. This path flows smoothly by high-speed train and avoids backtracking. It balances history, art, food, and scenery. It’s one of the most efficient ways to spend 10 days in Italy.

    How many cities should you visit in 10 days in Italy?

    Three main cities plus a few day trips work best. Visiting too many places can feel rushed. Stick to Rome, Florence, and Venice, then add Tuscany, Amalfi Coast, or the Dolomites as side trips.

    What is the best way to get around Italy in 10 days?

    High-speed trains are the easiest and fastest option. They connect major cities quickly and comfortably. For day trips, guided tours simplify logistics and save time. Trains and tours together make traveling during your 10 days in Italy stress-free.

    When is the best time to do a 10-day Italy itinerary?

    Spring (April to June) and fall (September to October) offer pleasant weather and fewer crowds. Summer is lively but hotter and busier. Choose shoulder seasons if you want milder temperatures and easier sightseeing.

    Book your Italy trip now!

    Gondola ride at Venice, Italy
    Feel free to adjust the number of days in your Italy itinerary to fit your interests! Are only looking for a Northern Italy itinerary? You may combine Como (with Lake Como), Dolomites, Verona & Venice as your unique Northern Italy itinerary. If you prefer sun and beaches, combine southern cities in your itinerary! Book train tickets on Klook and start your Italy exploration now!

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    Our mission is to build the digital infrastructure for the global experience economy — empowering merchants to share their passions and travelers to discover the heartbeat of each destination. We operate a mobile-first, curated platform featuring diverse experiences across global destinations.
    ✨ Follow us for more deals and inspiration for your upcoming travels
    📸 Instagram | 📱 TikTok | ✏️ Blog | 🔴 YouTube
    What is Klook?
    Klook is a leading pan-regional experiences platform in Asia Pacific, purpose built to digitalize experiences and make them accessible to every traveler.
    Our mission is to build the digital infrastructure for the global experience economy — empowering merchants to share their passions and travelers to discover the heartbeat of each destination. We operate a mobile-first, curated platform featuring diverse experiences across global destinations.
    ✨ Follow us for more deals and inspiration for your upcoming travels
    📸 Instagram | 📱 TikTok | ✏️ Blog | 🔴 YouTube
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