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Guests and rooms

2 adults, 1 room

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21C Museum Hotel St Louis

1528 Locust streetSee map

$ 237.57per night

This is the cheapest price in 30 days, based on the rates on 15 Nov

Top reasons for booking
Great view
Most user reviews comment positively on the view from their room
Popular facilities
Bar
Coffee shop
Restaurant
Free WiFi
Fitness center
Spa
4.5/5Fantastic 2K+ reviews
Exploring the area
Union Station - West Lot, 800m, About 13 mins from hotel by foot
St. Louis Union Station, 500m, About 9 mins from hotel by foot
Lambert–St. Louis International Airport, 18.9km, About 22 mins from hotel by car
7
Deluxe Room, 1 King Bed
1 double bed or bigger

29.0 m²

8
Luxury Double Room, 2 Queen Beds
Bed type arranged at check-in

39.0 m²

4
Room (Bunk Bed)
1 single bed

22.0 m²

4
Loft, 2 Queen Beds
Bed type arranged at check-in

40.0 m²

2
Deluxe Room, Accessible (Accessible)
1 double bed or bigger

25.0 m²

5
Suite, 1 King Bed (21C)
1 double bed or bigger

104.0 m²

3
Suite, 1 King Bed (Library)
1 double bed or bigger

68.0 m²

City view

4
Luxury Suite, 1 King Bed
1 double bed or bigger

51.0 m²

3
Deluxe Room, 1 Double Bed, Accessible
1 double bed or bigger

36.0 m²

2
Deluxe Suite, 1 Double Bed, Accessible
1 double bed or bigger

48.0 m²

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Reviews

Read all reviews
4.5/5.0

Fantastic

2K+ reviews
Location
0.0
Services offered
4.5
Cleanliness
4.6
Atmosphere & facilities
4.5
All
4.5+
3.0+
Amanda
Reviewed: 18 Jul 2026

5.0/5.0

Fantastic

Stayed with partner

Such a unique space! Art is emeshed throughout the entire building, creating a warm, inviting space (and a ton of photo ops). Every staff member we encountered was kind, engaging, and helpful. Having access to the pool and fitness center was wonderful for our stay. Breakfast at Good Press was 10/10. We will definitely be back!
Jentre
Reviewed: 18 Jul 2026

5.0/5.0

Fantastic

Stayed with partner

Great interesting hotel. The steam room and sauna and gym are an absolute bonus!
Mark C
Reviewed: 16 Jul 2026

5.0/5.0

Fantastic

Stayed with family

clean and nice bar area with outdoor seating area.
Meredith
Reviewed: 15 Jul 2026

5.0/5.0

Fantastic

For business

The spa is so amazing, we’d come to St. Louis just for this amenity; loved the galleries too!
Joe
Reviewed: 12 Jul 2026

5.0/5.0

Fantastic

Stayed with partner

The hotel room was beautiful and very comfortable! The restaurant was amazing, museum was awesome and location was close to everything!
Traci
Reviewed: 12 Jul 2026

5.0/5.0

Fantastic

Stayed with partner

Art + bar = perfect
Ancharmaine
Reviewed: 10 Jul 2026

5.0/5.0

Fantastic

Stayed with partner

We Love This Place! Will definitely book here everytime we are in The Lou!
Rina
Reviewed: 8 Jul 2026

5.0/5.0

Fantastic

Stayed with kids

We really enjoyed our stay here and would be back for sure! Property is very clean and staff is really hospitable and accommodating.
Krista
Reviewed: 5 Jul 2026

4.0/5.0

Great

Stayed with kids

The parking situation is a little awkward, and the restaurants are VERY overpriced, but overall it's an amazing hotel with an amazing pool and amazing art.
Todd
Reviewed: 5 Jul 2026

5.0/5.0

Fantastic

Stayed with family · For friends and family

The staff at this hotel were top notch. Excellent employees only added to the beauty of this hotel. Our room was lovely. The beds were top quality. The layout and yhe artwork made it seem less like a hotel and more like home. The hotel itself is gorgeous. My favorite hotel so far in life.

Overview

21C Museum Hotel St Louis

First open:2023-01-01
Rooms:104
Star rating:

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. This luxury hotel is 0.4 mi (0.7 km) from Enterprise Center and 0.7 mi (1.1 km) from America's Center Convention Complex.

Description

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. This luxury hotel is 0.4 mi (0.7 km) from Enterprise Center and 0.7 mi (1.1 km) from America's Center Convention Complex.

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Exploring the area

Transport

Union Station - West Lot

Metro stations
800m

St. Louis Union Station

Train stations
500m

Lambert–St. Louis International Airport

Airports
18.9km

Attractions

Campbell House Museum

100m

City Museum

300m

Lucas Garden Park

300m

Citygarden

400m

Peabody Opera House

400m

Meeting of the Waters Fountain

500m

Enterprise Center

600m

St. Louis City Hall

600m
See map

Facilities & services

Popular facilities
Bar
Coffee shop
Restaurant
Free WiFi
Fitness center
Spa
General
Non-smoking throughout
Elevator
Accessibility
Valet parking (additional charge)
Vending machine
Business facilities
Business center
Meeting facilities
Banquet facilities
Cleaning services
Laundry service
Reception services
24-hour front desk
Luggage storage
Concierge
ATM/Bank
Health & fitness
Sauna
Indoor Swimming pool
Accessibility
Wheelchair accessible
Braille or raised signage
Wheelchairs available on site
Food & drink
Breakfast service (additional charge)
See all facilities

Property policies

Check-in/out Time

Earliest check-in time:After 16:00 - Before 11:00

Latest check-out time:Before 11:00

Check-in policy

The guest responsible for check-in must be aged 21 or above

Special check-in instructions

Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.

Check-in descriptions

Extra-person charges may apply and vary depending on property policy

Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges

Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed

This property accepts credit cards; cash is not accepted

Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting

Note: Check-in policies vary by property. Please check carefully before booking

Child Policy

Children at all ages are welcome to stay at this property

Children aged above 12 will be charged as adults at this property

Mandatory fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Other fees

Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person

Valet parking fee: USD 50 per day (in/out privileges)

Pet fee: USD 100 per accommodation, per stay

Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

Food & drinks

Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee.

See all policies
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