Where to?

Check-in/out dates

Select your dates

Guests and rooms

2 adults, 1 room

Find more hotels in Jacksonville

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

4905 SAN PABLO ROAD SOUTHSee map

€ 138.46per night

This is the cheapest price in 30 days, based on the rates on 22 Nov

Top reasons for booking
With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 1-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center. This hotel is 10.3 mi (16.5 km) from Mayport Naval Station and 5.2 mi (8.4 km) from University of North Florida.
Popular facilities
Bar
Free WiFi
Fitness center
24-hour front desk
Luggage storage
Business center
4.7/5Fantastic 615 reviews
Exploring the area
Jacksonville Station, 30.3km, About 34 mins from hotel by car
Jacksonville Executive at Craig Airport, 11.8km, About 14 mins from hotel by car
6
Studio, 1 King Bed with Sofa bed, Corner
2 beds

50.0 m²

9
Studio Suite, 1 Bedroom, Corner
Multiple beds

60.0 m²

8
Studio Suite, 1 King Bed with Sofa bed
2 beds

38.0 m²

7
Studio Suite, 1 Bedroom
Multiple beds

52.0 m²

6
Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Tub)
2 beds

38.0 m²

6
Studio Suite, 1 King Bed with Sofa bed (Hearing Accessible)
2 beds

38.0 m²

6
Studio Suite, 1 King Bed with Sofa bed (Mobility Accessible, Roll-In Shower)
2 beds

38.0 m²

5
Studio Suite, 1 Bedroom (Hearing Accessible)
Multiple beds

52.0 m²

5
Studio, 1 King Bed with Sofa bed, Corner (Hearing Accessible)
2 beds

50.0 m²

6
Studio Suite, 1 Bedroom, Corner (Mobility/Hearing Access, Roll-In Shwr)
Multiple beds

60.0 m²

Earn KlookCash for this booking & save on the next one

Reviews

Read all reviews
4.7/5.0

Fantastic

615 reviews
Location
0.0
Services offered
4.8
Cleanliness
4.8
Atmosphere & facilities
4.6
All
4.5+
3.0+
Linda
Reviewed: 5 Aug 2026

5.0/5.0

Fantastic
I had a very nice day there
Laura
Reviewed: 3 Aug 2026

5.0/5.0

Fantastic
Great prices for the rooms and amenities they come with. Best hotel breakfast Ive seen in a while- all the extras and more!
Kendra LaToya
Reviewed: 31 Jul 2026

5.0/5.0

Fantastic
Very clean facility. Suite was perfect for our family of 4. Gym was well-equipped.
NICKOLAS
Reviewed: 27 Jul 2026

4.0/5.0

Great
ok
Devonta
Reviewed: 21 Jul 2026

5.0/5.0

Fantastic

Stayed with kids

I stayed at this hotel for 3 days. It was super clean and comfortable to stay the night for vacation.
Mitchell
Reviewed: 19 Jul 2026

5.0/5.0

Fantastic

Stayed with family

Well maintained and the staff extremely professional!!
Walter
Reviewed: 18 Jul 2026

5.0/5.0

Fantastic
All good
Isabel
Reviewed: 18 Jul 2026

5.0/5.0

Fantastic

Stayed with partner

Todo muy bien
Sheri
Reviewed: 17 Jul 2026

5.0/5.0

Fantastic

Stayed with partner

Great clean hotel. The location is perfect for Mayo Clinic guests. Our bed was comfortable and the room is laid out very nicely with a small kitchen, full-size refrigerator, and a walk-in shower. We had dinner in the hotel bar area and it was very good. The staff is very funny.
Bryce
Reviewed: 16 Jul 2026

5.0/5.0

Fantastic

Stayed with family · For friends and family

Great and clean hotel and staff

Overview

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Rooms:155
Floors:7
Star rating:

With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 1-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center. This hotel is 10.3 mi (16.5 km) from Mayport Naval Station and 5.2 mi (8.4 km) from University of North Florida.

Description

With a stay at Residence Inn By Marriott Jacksonville - Mayo Clinic Area in Jacksonville (Isle of Palms), you'll be a 1-minute drive from Mayo Clinic Florida and 9 minutes from St. Johns Town Center. This hotel is 10.3 mi (16.5 km) from Mayport Naval Station and 5.2 mi (8.4 km) from University of North Florida.

See all

Exploring the area

Transport

Jacksonville Station

Train stations
30.3km

Jacksonville Executive at Craig Airport

Airports
11.8km
See map

Facilities & services

Popular facilities
Bar
Free WiFi
Fitness center
24-hour front desk
Luggage storage
Business center
General
Free parking
Non-smoking throughout
Fireplace
Shop
Elevator
Accessibility
Housekeeping
Wedding services
Uncovered parking
Garden
Safety & security
Safety deposit box
Business facilities
Meeting facilities
Banquet facilities
Cleaning services
Laundry service
Reception services
Concierge
Fast check-out
Multilingual staff
Health & fitness
Outdoor Swimming pool
Accessibility
Wheelchair accessible
Assistive listening devices available
Braille or raised signage
Wheelchair accessible parking
Food & drink
Poolside bar
Free breakfast
Activities
Ballroom
See all facilities

Property policies

Check-in/out Time

Earliest check-in time:After 16:00 - Before 06:00

Latest check-out time:Before 11:00

Check-in policy

The guest responsible for check-in must be aged 21 or above

Special check-in instructions

If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation. Front desk staff will greet guests on arrival at the property. Information provided by the property may be translated using automated translation tools.

Check-in descriptions

Extra-person charges may apply and vary depending on property policy

Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges

Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed

This property accepts credit cards; cash is not accepted

Cashless transactions are available

Safety features at this property include a carbon monoxide detector, a fire extinguisher, a smoke detector, and window guards

Note: Check-in policies vary by property. Please check carefully before booking

Child Policy

Children at all ages are welcome to stay at this property

Mandatory fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

Deposit: USD 125 per accommodation, per stay

We have included all charges provided to us by the property.

Other fees

Pet fee: USD 150 per accommodation, per stay

Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

Food & drinks

Grab a bite from the grocery/convenience store serving guests of Residence Inn By Marriott Jacksonville - Mayo Clinic Area. Relax with your favorite drink at the bar/lounge or the poolside bar. A complimentary buffet breakfast is served on weekdays from 6:30 AM to 9:00 AM and on weekends from 7:00 AM to 9:30 AM.

See all policies
Home United States Florida Jacksonville Hotels in Jacksonville Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Explore more on Klook

Everything you need for your Jacksonville visit

Top destinations in United States